2002 General Immune System Function
With LRI funding, Dr. Taneja aimed to establish a molecular explanation of why mice lacking the T cell transcription factor Stra13 develop a lupus-like disease.
She published several papers on her findings, and initiated a collaboration with an NIH group to examine if human lupus patients have mutations in Stra-13.
Although she was no longer active in lupus research by 2010, Dr. Taneja notes that “the findings from LRI-funded research have helped us identify the mechanisms underlying additional phenotypes in our mutant mice. In particular, changes in cytokine expression in Stra13-/- mice appear to also be important in defective skeletal muscle regeneration [Vercherat et al., 2009 Nov 15;18(22):4304-16.]
“The LRI has been one of the best agencies I have worked with. Their meetings are small and promote interactions. The annual nature of the meetings and their all-inclusiveness (all grantees are invited) is excellent.” – Dr. Taneja
Sharp-1/DEC2 inhibits skeletal muscle differentiation through repression of myogenic transcription factors. Azmi S, Ozog A, Taneja R. J Biol Chem. 2004 Dec 10;279(50):52643-52. Epub 2004 Sep 22.
mSharp-1/DEC2, a basic helix-loop-helix protein functions as a transcriptional repressor of E box activity and Stra13 expression. Azmi S, Sun H, Ozog A, Taneja R. J Biol Chem. 2003 May 30;278(22):20098-109. Epub 2003 Mar 25.
The transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs. Grechez-Cassiau A, Panda S, Lacoche S, Teboul M, Azmi S, Laudet V, Hogenesch JB, Taneja R, Delaunay F. J Biol Chem. 2004 Jan 9;279(2):1141-50. Epub 2003 Oct 27.
Rev. July 2010